Fig. 3
From: Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression
PC depletion remodels tumor immune landscape to promote tumor growth. A Tumor mass from M-Wnt tumors harboring control (scram) or PC-targeted (shPC-C) constitutive shRNAs (n = 5/group). B–L Flow cytometric analysis of CD45+ cells from M-Wnt tumors harboring control (scram) or PC-targeted (ShPC-C) constitutive shRNAs (n = 5/group). Tumor growth over time (M), terminal tumor mass (N), and terminal body mass (O) of NSG mice bearing M-Wnt tumors harboring control (scram) or PC-targeted (shPC-C) constitutive shRNAs (n = 10/group). Tumor growth over time (P), terminal tumor mass (Q), and terminal body mass (R) of NSG mice bearing E0771 tumors harboring control (scram) or PC-targeted (shPC25) constitutive shRNAs (n = 10/group). Statistical significance was determined by unpaired student’s t-test