Fig. 2
From: Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression
Depletion of PC increases primary tumor growth and suppresses immune related gene expression. A Tumor mass from M-Wnt tumors harboring control (scram) or PC-targeted (ShPC-C) constitutive shRNAs (n = 6/group). B Tumor volume and C tumor mass from M-Wnt tumors harboring PC-targeted dox inducible shRNA treated with (+Dox) or without doxycycline (- Dox) (n = 5/group). D Hallmark GSEA of transcriptomic profile of tumors from B-C, which were significantly enriched with FRDq < 0.05 (n = 5/group). E Enrichment maps of significant (FDRq < 0.05) GSEA Gene Ontology Biological processes in Ctrl and shPC tumors. (FDRq < 0.05). Node color indicates normalized enrichment score, node size indicates gene set size, line weight indicates degree of overlap, and clusters indicate minimum 50% overlap of gene sets. Statistical significance was determined by unpaired student’s t-test (A–C)