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Fig. 2 | Breast Cancer Research

Fig. 2

From: In situ HER2 RNA expression as a predictor of pathologic complete response of HER2-positive breast cancer patients receiving neoadjuvant chemotherapy and anti-HER2 targeted treatment

Fig. 2

Correlation between HER2 RNAscope scores and pCR rates in the 270 patients with HER2-positive BCs receiving NCTT, and representative images of HER2 and PPIB RNAscope scores with corresponding HER2 IHC and FISH. Barplots of the pCR rates in patients stratified by HER2 RNAscope scores 1–5 (A) and 1–4 versus 5 (B). (C) Dotplot denoting HER2 RNAscope scores in patients with or without pCR. Mean is shown as red line. (D) Representative BCs with HER2 RNAscope score 1, 2, 3, 4 or 5 (upper panel), with corresponding control PPIB RNAscope scores (middle panel), HER2 IHC (lower panel) and HER2 FISH (inset in lower panel). (E) A representative case of HER2 RNAscope (left panel), IHC (middle panel) and FISH (right panel) is shown. Star, non-neoplastic mammary duct. ****p < 0.0001

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Breast Cancer Research

ISSN: 1465-542X

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