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Fig. 5 | Breast Cancer Research

Fig. 5

From: EDI3 knockdown in ER-HER2+ breast cancer cells reduces tumor burden and improves survival in two mouse models of experimental metastasis

Fig. 5

EDI3 knockdown in HCC1954-luc cells reduces metastatic burden. A Ex vivo luminescence imaging of organs and 100 μl ascites fluid (if present) with corresponding quantitative analysis B six and C eight weeks after intraperitoneal injection of doxycycline-induced and non-induced HCC1954-luc shEDI3 cells. Quantitative analysis of luminescence signal analyzed per organ after D six and E eight weeks. F Tables representing the ratio of mice positive for tumors in a specific organ compared to all mice six (left panel) and eight (right panel) weeks after injection. Data represent results of seven mice per condition. Box plots: horizontal line, median; box, 25th–75th percentiles; whiskers, min to max (*p < 0.05; **p < 0.01). l, liver; d, diaphragm; k, kidney; s/s/p, complex of spleen, stomach, and pancreas; a, ascites fluid; g, gonadal white adipose tissue (WAT)

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Breast Cancer Research

ISSN: 1465-542X

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