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Fig. 4 | Breast Cancer Research

Fig. 4

From: Evaluating the immunologically “cold” tumor microenvironment after treatment with immune checkpoint inhibitors utilizing PET imaging of CD4 + and CD8 + T cells in breast cancer mouse models

Fig. 4

The spatial heterogeneity of intratumoral CD4 and CD8 PET signals was reduced in responders. A) Representative images of isolated 3D tumors and 2D slices of PET image. B) Representative topographic map of 2D slice PET images. In the MMTV-HER2 model, non-responders showed increased peak numbers of [89Zr]Zr-DFO-CD8 uptake compared to responders. C-J) Quantification of regional hotspot numbers in 3D tumors. In both MMTV-HER2 and 4T1 models, the responders showed decreased regional hotspot numbers of [89Zr]Zr-DFO-CD8 and [89Zr]Zr-DFO-CD4 uptake compared to non-responders after initiation of ICB (day 6)

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Breast Cancer Research

ISSN: 1465-542X

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