Fig. 2
From: Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation
RhoC overexpression cooperates with endogenously driven activated Neu (FloxNeoNeuNT) to enhance tumor formation. A Kaplan Meier survival curve showing cooperation between FloxNeoNeuNT and RhoC overexpression. Death due to mammary tumor end-point was compared between cohorts. Statistical analysis for KM survival curves was calculated using Log-rank (Mantel-Cox) test via GraphPad Prism (shown in the table below) and p-values of less than 0.05 are considered significant (red text). B Graph comparing the ages between cohorts at the end-point due to mammary gland tumors. C The column graph shows the mammary tumor histology. Tumor types are represented with different colors. Mammary tumor histotypes are divided as below. ASC, Adenosquamous carcinoma; SC, Squamous cyst; SCC, Squamous cell carcinoma; PDA, Poorly differentiated adenocarcinoma; Pap, Papillary adenocarcinoma; SNC, Solid nodular carcinoma; AME, Adenomyoepithelioma; CAC, Complex adenocarcinoma; STC, Scirrhous tubular carcinoma; SCT, Spindle cell tumor. FloxNeoNeuNT controls (or NeuNT controls) contain data from FloxNeoNeuNT;MMTV-CreNLST and Gata4loxP/+;FloxNeoNeuNT;MMTV-CreNLST cohorts (for separate analysis of these cohorts, see Additional file 1: Supplementary Figure S4). Note: CreT = CreNLST