Fig. 4

Main hub nodes identification of subnetwork B and association with OS and RFS. The top ten hub nodes of subnetwork B (A) interactions were mapped through PPI network analysis (B). Kaplan-Meier analysis of OS and RFS was performed to validate the relevance of the gene signature (including CDK1, PCNA, EZH2, and BUB1) in other IDC patients. OS (C) and RFS (D) analysis were analyzed through METABRIC database where blue indicates patients with low gene expression and red indicates patients with high gene expression