Fig. 2

Mutational landscape of DTBC tumors in reference to LumA tumors. (A) Subtypes and recurrence status of tumors in top panel are sorted by DTBC and then LumA subtypes. (B) Oncoplot displaying the significantly mutated genes (SMG) enriched in DTBC tumors. Types of mutations in each gene are shown by a colored cell. Mutation frequency is shown on the right for each gene. Genes are ordered by their enrichment (DTBC versus LumA) and then sorted by p-value. (C) Tumor mutational burden (TMB) reported in terms of absolute non-synonymous mutations. (D) Significant chromosome arm level amplification and deletion peaks differentially enriched between DTBC and LumA tumors. (E) Somatic copy number alterations (SCNA)-based SMG differentially enriched between DTBC and LumA tumors