Table 2 Univariate negative binomial regression models assessing associations between cohort characteristics with CD163+ cell density in the overall sample and within Black and White cases
Characteristic | Overall | Black | White | ||||||
|---|---|---|---|---|---|---|---|---|---|
n | Median (IQR)a | p-value | n | Median (IQR)a | p-value | n | Median (IQR)a | p-value | |
Total | 611 | 203.7 (451.3) | 507 | 223.2 (497.2) | 104 | 142.5 (266.6) | |||
Age at diagnosis | 0.025 | 0.054 | 0.083 | ||||||
< 40 | 63 | 314.6 (836.4) | 52 | 347.4 (924.7) | 11 | 141.5 (540.3) | |||
40–50 | 158 | 191.5 (369.6) | 125 | 207.3 (417.8) | 33 | 156.4 (251.5) | |||
50–60 | 201 | 197.0 (453.8) | 169 | 201.4 (502.1) | 32 | 118.6 (268.5) | |||
60+ | 189 | 207.3 (371.5) | 161 | 225.4 (402.0) | 28 | 143.9 (273.7) | |||
BMI | 0.81 | 0.32 | 0.47 | ||||||
< 25 | 123 | 191.5 (430.5) | 81 | 246.2 (753.9) | 42 | 118.3 (234.5) | |||
25–30 | 184 | 174.2 (431.3) | 153 | 188.8 (421.1) | 31 | 141.5 (410.2) | |||
30–35 | 154 | 243.4 (526.4) | 137 | 255.0 (525.5) | 17 | 104.1 (238.8) | |||
35+ | 149 | 221.6 (423.4) | 135 | 221.4 (488.7) | 14 | 276.1 (178.8) | |||
ER status | < 0.001 | < 0.001 | 0.10 | ||||||
ER+ | 419 | 140.3 (295.2) | 337 | 153.1 (303.3) | 82 | 99.5 (229.1) | |||
ER− | 192 | 436.3 (884.4) | 170 | 466.8 (961.0) | 22 | 296.8 (623.7) | |||
Subtype | < 0.001 | < 0.001 | 0.14 | ||||||
Luminal | 359 | 130.8 (256.8) | 293 | 139.0 (278.6) | 66 | 88.7 (194.0) | |||
HER2+ | 104 | 308.3 (413.8) | 81 | 314.6 (364.9) | 23 | 281.5 (466.5) | |||
Triple negative | 143 | 526.3 (1,083.1) | 128 | 574.3 (1,127.0) | 15 | 245.0 (431.5) | |||
Stage | < 0.001 | 0.002 | 0.20 | ||||||
I | 260 | 149.6 (310.0) | 217 | 187.7 (343.4) | 43 | 84.5 (161.1) | |||
II | 269 | 243.0 (521.0) | 222 | 258.3 (628.7) | 47 | 167.1 (288.4) | |||
III/IV | 82 | 237.9 (484.8) | 68 | 242.2 (427.9) | 14 | 183.9 (593.4) | |||
Grade | < 0.001 | < 0.001 | 0.022 | ||||||
1 | 82 | 82.0 (130.5) | 63 | 84.0 (156.1) | 19 | 52.5 (123.5) | |||
2 | 213 | 114.2 (226.0) | 167 | 130.5 (247.9) | 46 | 79.8 (129.7) | |||
3 | 307 | 362.5 (678.6) | 271 | 365.3 (689.2) | 36 | 321.1 (591.9) | |||
Tumor size (cm) | 0.002 | 0.005 | 0.48 | ||||||
< 1 | 67 | 111.9 (280.9) | 55 | 130.5 (309.2) | 12 | 33.9 (106.0) | |||
1–2 | 233 | 192.1 (363.5) | 190 | 207.3 (430.6) | 43 | 143.5 (234.3) | |||
2+ | 306 | 236.7 (521.5) | 257 | 261.7 (535.3) | 49 | 165.6 (300.8) | |||
Node status | 0.44 | 0.59 | 0.33 | ||||||
Positive | 242 | 211.9 (463.2) | 197 | 221.6 (494.1) | 45 | 165.6 (321.1) | |||
Negative | 357 | 199.6 (449.4) | 299 | 227.9 (493.7) | 58 | 108.5 (237.9) | |||