Fig. 6
From: TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity
TRPS1 represses SRF/MRTF activity via indirect modulation of RhoA activity a Heatmap of TRPS1 Cut&Run binding peaks in promoters (n = 725). IgG serves as negative control. b Venn diagram of the distribution of TRPS1 binding peaks in the genome. TSS = Transcription Start Site; Interg. = Intergenic region; UTR = Untranslated region. c Scatter plot for the enrichment of C2H2 and GATA binding motifs in regions bound by TRPS1 identified by Cut&Run. d Schematic of the strategy used to select TRPS1-target genes involved in the regulation of actin dynamics. e Cut&Run genomic tracks for TRPS1 binding (Red) and control IgG (Gray) centered on the promoter regions of the indicated genes. Green boxes mark the position of the Cut&Run peaks