Table 2 Univariate Cox proportional regression analysis on 5-year overall and disease-free survival of 344 breast cancer patients
Parameter | Overall survival | Disease-free survival | ||||
|---|---|---|---|---|---|---|
Hazard ratio | 95% Cl | P value | Hazard ratio | 95% Cl | P value | |
AUF1 (fibroblasts) | ||||||
≥ 10% | 1.000 | 1.000 | ||||
< 10% | 0.544 | 0.333–0.889 | 0.0151 | 0.705 | 0.484–1.026 | 0.0677 |
AUF1 (cancer cells) | ||||||
≥ 10% | 1.000 | 1.000 | ||||
< 10% | 0.945 | 0.589–1.516 | 0.8152 | 0.969 | 0.688–1.366 | 0.8579 |
Tumor size | ||||||
T2 | 1.000 | 1.000 | ||||
T3 | 1.703 | 0.842–3.448 | 0.1387 | 1.353 | 0.826–2.216 | 0.2304 |
T4 | 2.296 | 1.168–4.516 | 0.016 | 1.95 | 1.223–3.109 | 0.005 |
Age | ||||||
≤ 50 years | 1.000 | 1.000 | ||||
> 50 years | 1.357 | 0.828–2.223 | 0.2257 | 0.946 | 0.645–1.388 | 0.7774 |
Lymph node | ||||||
N0 | 1.000 | 1.000 | ||||
N1 | 1.084 | 0.454–2.586 | 0.856 | 1.286 | 0.680–2.429 | 0.4392 |
N2 | 2.311 | 0.954–5.6 | 0.0636 | 2.187 | 1.13–4.230 | 0.0201 |
N3 | 1.39 | 0.466–4.145 | 0.5546 | 1.631 | 0.74–3.596 | 0.2251 |
Stage | ||||||
IIA | 1.000 | 1.000 | ||||
IIIA | 1.921 | 0.932–3.963 | 0.0771 | 2.257 | 1.332–3.822 | 0.0025 |
IIIB | 2.612 | 1.336–5.106 | 0.005 | 2.67 | 1.624–4.389 | 0.0001 |
Grade | ||||||
G1 | 1.000 | 1.000 | ||||
GII | 0.938 | 0.128–6.868 | 0.9495 | 0.869 | 0.212–3.554 | 0.845 |
GIII | 1.336 | 0.183–9.762 | 0.7754 | 1.037 | 0.253–4.249 | 0.9597 |
ER/Her2 status | ||||||
ER(+ve)/Her2(+ve) | 1.000 | 1.000 | ||||
ER(+ve)/Her2(−ve) | 0.612 | 0.267–1.404 | 0.2458 | 0.522 | 0.297–0.917 | 0.0237 |
ER(-ve)/Her2(+ve) | 1.52 | 0.855–2.699 | 0.1535 | 0.929 | 0.602–1.434 | 0.7393 |
ER(−ve)/Her2(−ve) | 1.417 | 0.783–2.564 | 0.2494 | 1.025 | 0.667–1.575 | 0.9107 |